- Panama City (PTY) Santiago de Chile (SCL)
- Sun
- Mon
- Tue
- Wed
- Thu
- Fri
- Sat
5–6 Non-stop flights per dayat least 5h 30minfrom $669 - Panama City (PTY) San Jose, Costa Rica (SJO)
- Sun
- Mon
- Tue
- Wed
- Thu
- Fri
- Sat
1–10 Non-stop flights per dayat least 1h 15minfrom $235 - Panama City (PTY) Managua (MGA)
- Sun
- Mon
- Tue
- Wed
- Thu
- Fri
- Sat
1–2 Non-stop flights per dayat least 1h 41minfrom $384