Flight Routes from Knoxville to San Diego

Compare cheap outbound and return flights from Knoxville (TYS) to San Diego (SAN) and find the best offer from numerous airlines and travel agencies.

Cheapest roundtrip flight: from€444
Flight distance: 3,058 km
Time difference: -3 hours

Cheap flight offers from Knoxville to San Diego

sorted by price and recency

Mon, Jan 4 – Tue, Jan 19
14:55 – 19:11
TYS–SAN
7h 16min
1 stopover
06:15 – 15:13
SAN–TYS
5h 58min
1 stopover
€3,065
Mon, Jan 4 – Tue, Jan 19
11:27 – 17:02
TYS–SAN
8h 35min
1 stopover
07:00 – 19:07
SAN–TYS
9h 7min
1 stopover
€711
Mon, Jan 4 – Wed, Jan 20
14:55 – 19:11
TYS–SAN
7h 16min
1 stopover
22:10 – 09:45
SAN–TYS
8h 35min
1 stopover
€623
Mon, Jan 4 – Tue, Jan 19
18:25 – 22:34
TYS–SAN
7h 9min
1 stopover
11:20 – 23:19
SAN–TYS
8h 59min
1 stopover
€510
Mon, Jan 4 – Tue, Jan 19
18:25 – 23:42
TYS–SAN
8h 17min
1 stopover
06:15 – 15:13
SAN–TYS
5h 58min
1 stopover
€451

Flight schedule from Knoxville (TYS) to San Diego (SAN)

Select a travel date in the flight schedule for the route from Knoxville (TYS) to San Diego (SAN) and compare affordable flight deals.

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Matching outbound flightsTYS–SAN · 0 of 0

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November 8 – 14, 2026
November 15 – 21, 2026
November 22 – 28, 2026

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Important flight information

Discover more flights around Knoxville and San Diego

Departure airport	Airport Knoxville, TN (TYS)
Arrival airport	Airport San Diego - Lindberg Field International, CA (SAN)
Destination country	Flights to United States
Departure airport - Destination country	Knoxville, TN - United States

Alternative routes to United States

Flight Knoxville - Philadelphia from 340 $
Flight Knoxville - Chicago from 298 $
Flight Knoxville - Miami from 464 $
Flight Knoxville - New York from 353 $
Flight Knoxville - Washington DC from 278 $
Flight Knoxville - Boston from 318 $
Flight Knoxville - Newark from 353 $
Flight Knoxville - Phoenix - Sky Harbor from 372 $
Flight Knoxville - Denver from 374 $
Flight Knoxville - Fort Lauderdale from 178 $

Alternative flights to San Diego

Flight New York - San Diego from 358 $
Flight Las Vegas - San Diego from 111 $
Flight San Francisco - San Diego from 143 $
Flight Los Angeles - San Diego from 171 $
Flight Orlando - San Diego from 366 $
Flight Austin - San Diego from 190 $
Flight Seattle-Tacoma - San Diego from 237 $
Flight Miami - San Diego from 500 $
Flight Portland-Oregon - San Diego from 314 $
Flight Kona - San Diego from 546 $

Flight destinations with a similar price

Flight San Diego - Kirensk from 358 $
Flight San Diego - Toronto from 538 $
Flight San Diego - Tokyo Narita from 823 $
Flight San Diego - Tokyo from 823 $
Flight San Diego - London Heathrow from 729 $
Flight San Diego - Vancouver from 460 $
Flight San Diego - Loreto from 932 $
Flight San Diego - Los Cabos from 427 $
Flight San Diego - San Jose, Costa Rica from 511 $
Flight San Diego - Puerto Vallarta from 418 $

Flight destinations with a similar price

Flight Knoxville - Miami from 464 $
Flight Knoxville - Fayetteville from 441 $
Flight Knoxville - Flint from 429 $
Flight Knoxville - Saginaw from 416 $
Flight Knoxville - Rochester from 441 $
Flight Knoxville - Moline from 421 $
Flight Knoxville - Shreveport from 443 $
Flight Knoxville - New York from 416 $
Flight Knoxville - Nashville from 401 $
Flight Knoxville - Burbank from 478 $