Flight Routes from Des Moines to Jacksonville, Florida

Compare cheap outbound and return flights from Des Moines (DSM) to Jacksonville, Florida (JAX) and find the best offer from numerous airlines and travel agencies.

Cheapest roundtrip flight: from€396
Flight distance: 1,632 km
Time difference: +1 hour

Flight schedule from Des Moines (DSM) to Jacksonville, Florida (JAX)

Select a travel date in the flight schedule for the route from Des Moines (DSM) to Jacksonville, Florida (JAX) and compare affordable flight deals.

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Matching outbound flightsDSM–JAX · 0 of 0

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October 4 – 10, 2026
October 11 – 17, 2026
October 18 – 24, 2026

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Important flight information

Discover more flights around Des Moines and Jacksonville, Florida

Departure airport	Airport Des Moines, IA (DSM)
Arrival airport	Airport Jacksonville, Florida (JAX)
Destination country	Flights to United States
Departure airport - Destination country	Des Moines, IA - United States

Alternative routes to United States

Flight Des Moines - New York from 378 $
Flight Des Moines - Newark from 378 $
Flight Des Moines - Atlanta from 264 $
Flight Des Moines - Los Angeles from 372 $
Flight Des Moines - St.Petersburg-Clearwater from 226 $
Flight Des Moines - San Diego from 379 $
Flight Des Moines - Orlando from 396 $
Flight Des Moines - Chicago from 305 $
Flight Des Moines - Fort Lauderdale from 309 $
Flight Des Moines - Valparaiso from 506 $

Alternative flights to Jacksonville, Florida

Flight New York - Jacksonville, Florida from 321 $
Flight New York - Jacksonville, Florida from 356 $
Flight New Orleans - Jacksonville, Florida from 379 $
Flight Washington-DC - Jacksonville, Florida from 284 $
Flight Dallas - Jacksonville, Florida from 372 $
Flight Denver - Jacksonville, Florida from 351 $
Flight Los Angeles - Jacksonville, Florida from 360 $
Flight Phoenix - Sky Harbor - Jacksonville, Florida from 451 $
Flight Louisville - Jacksonville, Florida from 362 $
Flight Seattle-Tacoma - Jacksonville, Florida from 439 $

Flight destinations with a similar price

Flight Jacksonville, Florida - Toronto from 541 $
Flight Jacksonville, Florida - Sarajevo from 699 $
Flight Jacksonville, Florida - Panama City from 670 $
Flight Jacksonville, Florida - Zagreb from 779 $
Flight Jacksonville, Florida - Monterrey from 749 $
Flight Jacksonville, Florida - San Juan (Puerto Rico) from 257 $
Flight Jacksonville, Florida - Vancouver from 638 $
Flight Jacksonville, Florida - Toronto from 541 $
Flight Jacksonville, Florida - Frankfurt from 716 $
Flight Jacksonville, Florida - Graz from 496 $

Flight destinations with a similar price

Flight Des Moines - New York from 378 $
Flight Des Moines - Newark from 378 $
Flight Des Moines - Los Angeles from 372 $
Flight Des Moines - San Diego from 379 $
Flight Des Moines - Orlando from 396 $
Flight Des Moines - Austin from 379 $
Flight Des Moines - Phoenix - Sky Harbor from 431 $
Flight Des Moines - Salt Lake City from 379 $
Flight Des Moines - Sarasota-Bradenton from 432 $
Flight Des Moines - Chicago Midway from 364 $