| Outbound | Return | Airlines | Shop | Baggage | Price | ||
|---|---|---|---|---|---|---|---|
| Chicago Santiago de Chile | Outbound 06/25/26 2 Stopovers (ATL, MIA) LA8769, LA8990, LA0543 23h 10min | Return 06/30/26 2 Stopovers (MIA, ATL) LA0502, LA8640, LA6161 24h 34min |  LATAM Chile |  | $807 | ||
| Best option Chicago Santiago de Chile | Outbound 06/25/26 1 Stopover (PTY) CM0236, CM0171 14h 24min | Return 06/30/26 1 Stopover (PTY) CM0475, CM0228 36h 35min |  Copa Airlines |  | ? | $866 | |
| Chicago Santiago de Chile | Outbound 06/25/26 3 Stopovers (MEX, CUN, LIM) Y40703, Y40102, LA2457, LA2697 35h 25min | Return 06/30/26 2 Stopovers (LIM, MEX) H20804, Y43919, Y40702 28h 27min |  Volaris, LATAM Chile |  | $1,000 | ||
| Chicago Santiago de Chile | Outbound 06/25/26 1 Stopover (PTY) CM0229, CM0171 31h 05min | Return 06/30/26 1 Stopover (PTY) CM0139, CM0228 36h 06min | Copa Airlines |  | ? | $860 | |
| Chicago Santiago de Chile | Outbound 06/25/26 1 Stopover (PTY) CM0229, CM0395 27h 02min | Return 06/30/26 1 Stopover (PTY) CM0139, CM0844 26h 09min | Copa Airlines |  | $948 | ||
| Chicago Santiago de Chile | Outbound 06/25/26 2 Stopovers (MCO, PTY) F93044, CM0479, CM0172 31h 36min | Return 06/30/26 2 Stopovers (LIM, MEX) H20802, Y43919, Y40702 43h 47min |  Frontier Airlines, Copa Airlines |  | ? | $1,009 | |
| Chicago Santiago de Chile | Outbound 06/25/26 1 Stopover (LAX) DL1556, DL6012 21h 35min | Return 06/30/26 1 Stopover (ATL) DL0146, DL2738 21h 04min |  Delta Air Lines |  | ? | $3,321 |
Tips and tricks to help you find cheap flights from Chicago to Santiago de Chile
Favorite airline: LATAM Chile
The majority of passengers on the route Chicago – Santiago de Chile prefer to fly with LATAM Chile.
LATAM Chile
31 %
Copa
27 %
Spirit Airlines
15 %