Flight Routes from Chicago to Santiago de Chile

Trip type

Our cheapest offers for flights from Chicago to Santiago de Chile

Here you can compare cheap flights from Chicago (CHI) to Santiago de Chile (SCL) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santiago de Chile. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Best option
Chicago
Santiago de Chile
Outbound
08/20/26
1 Stopover (PTY)
CM0236, CM0474
17h 58min
Return
08/25/26
1 Stopover (PTY)
CM0139, CM0235
23h 06min
Copa Airlines ?
$676
found 3 days ago
Chicago
Santiago de Chile
Please note: transfer for connecting flight
Outbound
06/25/26
3 Stopovers (MEX, CUN, LIM)
Y40703, Y40102, LA2457, LA2697
35h 25min
Return
06/30/26
2 Stopovers (LIM, MEX)
H20804, Y43919, Y40702
28h 27min
Volaris, LATAM Chile
$1,000
Chicago
Santiago de Chile
Outbound
08/20/26
2 Stopovers (ATL, MIA)
LA6277, LA8990, LA0501
16h 05min
Return
08/25/26
2 Stopovers (MIA, ATL)
LA0500, LA6145, LA6278
20h 49min
LATAM Chile
$771
found 3 days ago
Chicago
Santiago de Chile
Outbound
08/20/26
3 Stopovers (MIA, MCO, PTY)
AA2400, AA3265, CM0868, CM0474
33h 50min
Return
08/25/26
1 Stopover (BOG)
AV0098, AV0262
15h 40min
American Airlines, Copa Airlines ?
$783
found 3 days ago
Chicago
Santiago de Chile
Outbound
08/20/26
1 Stopover (PTY)
CM0236, CM0497
13h 41min
Return
08/25/26
1 Stopover (PTY)
CM0139, CM0235
23h 06min
Copa Airlines
$789
found 3 days ago
Chicago
Santiago de Chile
Outbound
06/25/26
1 Stopover (PTY)
CM0229, CM0171
31h 05min
Return
06/30/26
1 Stopover (PTY)
CM0139, CM0228
36h 06min
Copa Airlines ?
$860
Chicago
Santiago de Chile
Outbound
06/25/26
1 Stopover (PTY)
CM0236, CM0171
14h 24min
Return
06/30/26
1 Stopover (PTY)
CM0475, CM0228
36h 35min
Copa Airlines ?
$866
Chicago
Santiago de Chile
Outbound
08/20/26
1 Stopover (BOG)
AV0263, AV0115
13h 55min
Return
08/25/26
1 Stopover (BOG)
AV0240, AV0262
21h 50min
Avianca
$899
found 3 days ago
Chicago
Santiago de Chile
Outbound
08/20/26
2 Stopovers (BOG, EOH, MDE)
AV0263, AV2914, JA5838
23h 51min
Return
08/25/26
1 Stopover (BOG)
AV0116, AV0262
31h 00min
Avianca, JetSmart
$913
found 3 days ago
Chicago
Santiago de Chile
Outbound
06/25/26
2 Stopovers (MCO, PTY)
F93044, CM0479, CM0172
31h 36min
Return
06/30/26
2 Stopovers (LIM, MEX)
H20802, Y43919, Y40702
43h 47min
Frontier Airlines, Copa Airlines ?
$1,009
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Chicago to Santiago de Chile

Favorite airline: LATAM Chile
The majority of passengers on the route Chicago – Santiago de Chile prefer to fly with LATAM Chile.
LATAM Chile
31 %
Copa
27 %
Spirit Airlines
15 %
Favourite connection: via Panama City
The most popular route is via Panama City and is booked by 32 % of all travelers.
Route
bookings
1 stopover Panama City-Tocumen International
27h 08min, from $584
32 %
1 stopover Hartsfield-Jackson Atlanta International Airport, GA
14h 08min, from $573
27 %
1 stopover New York - John F. Kennedy International Airport, NY
13h 54min, from $674
14 %

Important flight information

Flight information: Chicago - Santiago de Chile

Roundtrip from $675.60
Distance 8555 km
Departure airport Airport Chicago-IL, all airports (CHI)
Arrival airport Airport Santiago de Chile - Arturo Merino Benitez (SCL)
Destination country Flights to Chile
Departure airport - Destination country Chicago-IL, all airports - Chile
Alternative flights to Santiago de Chile
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