Flights from Chicago to Santiago de Chile

Our cheapest offers for flights from Chicago to Santiago de Chile

Here you can compare cheap flights from Chicago (CHI) to Santiago de Chile (SCL) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santiago de Chile. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Best option
Chicago
Santiago de Chile
Outbound
09/04/25
1 Stopover (BOG)
AV0263, AV0097
12h 40min
Return
09/28/25
1 Stopover (BOG)
AV0116, AV0262
23h 45min
Avianca ?
$587
Chicago
Santiago de Chile
Outbound
11/03/25
1 Stopover (MEX)
AM0689, AM0010
17h 15min
Return
11/12/25
1 Stopover (MEX)
AM0011, AM0686
16h 23min
Aeroméxico
$796
Chicago
Santiago de Chile
Outbound
09/04/25
1 Stopover (BOG)
AV0263, AV0115
21h 50min
Return
09/28/25
1 Stopover (BOG)
AV0116, AV0262
23h 45min
Avianca
$592
Chicago
Santiago de Chile
Outbound
09/04/25
1 Stopover (BOG)
AV0263, AV0097
12h 40min
Return
09/28/25
1 Stopover (BOG)
AV0116, AV0262
23h 45min
Avianca ?
$609
Chicago
Santiago de Chile
Outbound
09/04/25
1 Stopover (BOG)
AV0263, AV0115
21h 50min
Return
09/28/25
1 Stopover (BOG)
AV0116, AV0262
23h 45min
Avianca
$614
Chicago
Santiago de Chile
Outbound
09/04/25
1 Stopover (PTY)
CM0236, CM0497
13h 46min
Return
09/28/25
1 Stopover (PTY)
CM0396, CM0228
34h 32min
Copa Airlines ?
$644
Chicago
Santiago de Chile
Outbound
09/04/25
1 Stopover (JFK)
LA6489, LA0533
16h 14min
Return
09/28/25
1 Stopover (JFK)
LA0532, LA8441
19h 41min
LATAM Chile
$651
Chicago
Santiago de Chile
Outbound
09/04/25
1 Stopover (JFK)
LA6489, LA0533
16h 14min
Return
09/28/25
2 Stopovers (BOG, ATL)
LA0710, LA6352, LA6111
30h 32min
LATAM Chile ?
$665
Chicago
Santiago de Chile
Outbound
09/04/25
1 Stopover (ATL)
LA7922, LA6357
16h 44min
Return
09/28/25
1 Stopover (JFK)
LA0532, LA6549
15h 23min
LATAM Chile ?
$669
Chicago
Santiago de Chile
Outbound
09/23/25
2 Stopovers (MTY, MEX)
UA5292, AM0937, LA0621
20h 48min
Return
09/30/25
1 Stopover (JFK)
LA0532, LA6549
15h 23min
United Airlines, Aeroméxico, LATAM Chile ?
$678
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Chicago to Santiago de Chile

Favorite airline: LATAM Chile
The majority of passengers on the route Chicago – Santiago de Chile prefer to fly with LATAM Chile.
LATAM Chile
31 %
Copa
27 %
Spirit Airlines
15 %
Favourite connection: via Panama City
The most popular route is via Panama City and is booked by 32 % of all travelers.
Route
bookings
1 stopover Panama City-Tocumen International
27h 08min, from $ 584
32 %
1 stopover Hartsfield-Jackson Atlanta International Airport, GA
14h 08min, from $ 573
27 %
1 stopover New York - John F. Kennedy International Airport, NY
13h 54min, from $ 674
14 %

Important flight information

Flight information: Chicago - Santiago de Chile

Roundtrip from $ 586,43
Distance 8555 km
Departure airport Airport Chicago-IL, all airports (CHI)
Arrival airport Airport Santiago de Chile - Arturo Merino Benitez (SCL)
Destination country Flights to Chile
Alternative flights to Santiago de Chile
Flight destinations with a similar price