Flights from Chicago to Santiago de Chile

Our cheapest offers for flights from Chicago to Santiago de Chile

Here you can compare cheap flights from Chicago (CHI) to Santiago de Chile (SCL) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santiago de Chile. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Best option
Chicago
Santiago de Chile
Outbound
11/03/25
1 Stopover (BOG)
AV0263, AV0097
12h 35min
Return
11/12/25
1 Stopover (BOG)
AV0116, AV0262
23h 50min
Avianca ?
$615
Chicago
Santiago de Chile
Outbound
11/03/25
1 Stopover (MEX)
AM0689, AM0010
17h 15min
Return
11/12/25
1 Stopover (MEX)
AM0011, AM0686
16h 23min
Aeroméxico
$796
Chicago
Santiago de Chile
Outbound
11/03/25
1 Stopover (BOG)
AV0263, AV0115
21h 45min
Return
11/12/25
1 Stopover (BOG)
AV0116, AV0262
23h 50min
Avianca
$616
Chicago
Santiago de Chile
Outbound
11/03/25
1 Stopover (MEX)
AM0687, AM0010
27h 48min
Return
11/12/25
1 Stopover (MEX)
AM0011, AM0686
16h 23min
Aeroméxico ?
$726
Chicago
Santiago de Chile
Outbound
11/03/25
1 Stopover (IAH)
UA0592, UA0847
13h 45min
Return
11/12/25
1 Stopover (IAH)
UA0846, UA0343
35h 55min
United Airlines ?
$738
Chicago
Santiago de Chile
Outbound
10/10/25
1 Stopover (ATL)
LA6595, LA6357
17h 41min
Return
11/04/25
1 Stopover (ATL)
LA6358, LA6161
13h 48min
LATAM Chile ?
$814
Chicago
Santiago de Chile
Outbound
11/03/25
1 Stopover (YYZ)
AC4994, AC0092
14h 30min
Return
11/12/25
1 Stopover (YYZ)
AC0093, AC0501
15h 07min
Air Canada ?
$849
Chicago
Santiago de Chile
Outbound
10/10/25
1 Stopover (ATL)
LA6597, LA6357
19h 30min
Return
11/04/25
1 Stopover (JFK)
LA0532, B62105
19h 13min
LATAM Chile ?
$881
Chicago
Santiago de Chile
Outbound
11/03/25
1 Stopover (IAH)
UA0592, UA0847
13h 45min
Return
11/12/25
1 Stopover (IAH)
UA0846, UA2417
19h 05min
United Airlines ?
$1,251
Chicago
Santiago de Chile
Outbound
10/10/25
1 Stopover (MIA)
AA2323, AA0957
13h 17min
Return
11/04/25
1 Stopover (DFW)
AA0940, AA1290
23h 05min
American Airlines ?
$1,468
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Chicago to Santiago de Chile

Favorite airline: LATAM Chile
The majority of passengers on the route Chicago – Santiago de Chile prefer to fly with LATAM Chile.
LATAM Chile
31 %
Copa
27 %
Spirit Airlines
15 %
Favourite connection: via Panama City
The most popular route is via Panama City and is booked by 32 % of all travelers.
Route
bookings
1 stopover Panama City-Tocumen International
27h 08min, from $ 584
32 %
1 stopover Hartsfield-Jackson Atlanta International Airport, GA
14h 08min, from $ 573
27 %
1 stopover New York - John F. Kennedy International Airport, NY
13h 54min, from $ 674
14 %

Important flight information

Flight information: Chicago - Santiago de Chile

Roundtrip from $ 614,14
Distance 8555 km
Departure airport Airport Chicago-IL, all airports (CHI)
Arrival airport Airport Santiago de Chile - Arturo Merino Benitez (SCL)
Destination country Flights to Chile
Alternative flights to Santiago de Chile
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