Flights from Chicago to Santiago de Chile

Trip type

Our cheapest offers for flights from Chicago to Santiago de Chile

Here you can compare cheap flights from Chicago (CHI) to Santiago de Chile (SCL) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santiago de Chile. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Best option
Chicago
Santiago de Chile
Outbound
05/16/26
1 Stopover (JFK)
LA6528, LA0533
16h 46min
Return
05/29/26
1 Stopover (JFK)
LA0532, LA6544
19h 40min
LATAM Chile
$569
Chicago
Santiago de Chile
Please note: transfer for connecting flight
Outbound
05/16/26
2 Stopovers (MIA, LIM)
NK1713, H85593, H20805
33h 56min
Return
05/29/26
3 Stopovers (PUJ, MIA, ATL)
DM6173, DM5100, NK3030, NK1823
35h 40min
Spirit Airlines, Sky Airline Peru, Sky Airline
$595
Chicago
Santiago de Chile
Outbound
05/16/26
1 Stopover (BOG)
AV0263, AV0115
13h 55min
Return
05/29/26
1 Stopover (PTY)
CM0498, CM0228
27h 49min
Avianca ?
$587
Chicago
Santiago de Chile
Outbound
05/16/26
1 Stopover (JFK)
LA6528, LA0533
16h 46min
Return
05/29/26
1 Stopover (ATL)
LA6358, LA6422
21h 09min
LATAM Chile ?
$631
Chicago
Santiago de Chile
Outbound
05/16/26
1 Stopover (BOG)
AV0263, AV0097
28h 25min
Return
05/29/26
1 Stopover (BOG)
AV0098, AV0262
15h 40min
Avianca ?
$671
Chicago
Santiago de Chile
Outbound
03/28/26
1 Stopover (BOG)
AV0263, AV0115
13h 05min
Return
04/25/26
2 Stopovers (LIM, MIA)
H25800, H85592, F92671
24h 04min
Avianca ?
$702
Chicago
Santiago de Chile
Outbound
07/26/26
1 Stopover (PTY)
CM0229, CM0172
33h 59min
Return
08/05/26
1 Stopover (PTY)
CM0498, CM0228
27h 37min
Copa Airlines ?
$726
Chicago
Santiago de Chile
Outbound
03/28/26
4 Stopovers (IAH, PTY, CLO, BOG)
UA2665, UA1916, UA7098, LA4070, LA0711
55h 45min
Return
04/25/26
2 Stopovers (LIM, MIA)
H20806, H85592, F93629
55h 35min
United Airlines, LATAM Chile ?
$745
Chicago
Santiago de Chile
Outbound
03/28/26
2 Stopovers (ATL, MIA)
LA6229, LA8994, LA0503
36h 36min
Return
04/25/26
1 Stopover (BOG)
AV0240, AV0262
14h 20min
LATAM Chile ?
$746
Chicago
Santiago de Chile
Outbound
07/26/26
3 Stopovers (YYZ, EWR, PTY)
UA1649, UA3711, UA0392, UA7072
52h 45min
Return
08/05/26
2 Stopovers (LIM, MIA)
H20802, H85592, F93629
32h 09min
United Airlines ?
$799
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Chicago to Santiago de Chile

Favorite airline: LATAM Chile
The majority of passengers on the route Chicago – Santiago de Chile prefer to fly with LATAM Chile.
LATAM Chile
31 %
Copa
27 %
Spirit Airlines
15 %
Favourite connection: via Panama City
The most popular route is via Panama City and is booked by 32 % of all travelers.
Route
bookings
1 stopover Panama City-Tocumen International
27h 08min, from $ 584
32 %
1 stopover Hartsfield-Jackson Atlanta International Airport, GA
14h 08min, from $ 573
27 %
1 stopover New York - John F. Kennedy International Airport, NY
13h 54min, from $ 674
14 %

Important flight information

Flight information: Chicago - Santiago de Chile

Roundtrip from $ 568,97
Distance 8555 km
Departure airport Airport Chicago-IL, all airports (CHI)
Arrival airport Airport Santiago de Chile - Arturo Merino Benitez (SCL)
Destination country Flights to Chile
Alternative flights to Santiago de Chile
Flight destinations with a similar price
Flight destinations with a similar price