Flights from Chicago to Santiago de Chile

Our cheapest offers for flights from Chicago to Santiago de Chile

Here you can compare cheap flights from Chicago (CHI) to Santiago de Chile (SCL) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santiago de Chile. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Chicago
Santiago de Chile
Outbound
02/13/26
1 Stopover (YYZ)
AC0506, AC0092
19h 15min
Return
02/26/26
1 Stopover (YYZ)
AC0093, AC0509
25h 35min
Air Canada ?
$660
Best option
Chicago
Santiago de Chile
Outbound
04/03/26
1 Stopover (PTY)
CM0236, CM0171
13h 57min
Return
04/16/26
1 Stopover (PTY)
CM0118, CM0228
14h 00min
Copa Airlines ?
$716
found 3 days ago
Chicago
Santiago de Chile
Please note: transfer for connecting flight
Outbound
04/03/26
2 Stopovers (MIA, LIM)
NK1713, H85591, H20807
26h 16min
Return
04/16/26
3 Stopovers (LIM, MIA, MSP)
H20804, H85590, SY0416, SY0261
23h 12min
Spirit Airlines, Sky Airline Peru, Sky Airline
$731
Chicago
Santiago de Chile
Outbound
04/03/26
1 Stopover (JFK)
LA6528, LA0533
15h 30min
Return
04/16/26
1 Stopover (JFK)
LA0532, LA6272
19h 46min
LATAM Chile
$706
found 3 days ago
Chicago
Santiago de Chile
Outbound
04/03/26
1 Stopover (PTY)
CM0236, CM0171
13h 57min
Return
04/16/26
1 Stopover (PTY)
CM0118, CM0235
25h 38min
Copa Airlines ?
$717
Chicago
Santiago de Chile
Outbound
02/13/26
1 Stopover (BOG)
AV0263, AV0115
14h 00min
Return
02/26/26
2 Stopovers (LIM, MIA)
H20802, H85590, NK3396
33h 35min
Avianca
$717
Chicago
Santiago de Chile
Outbound
02/13/26
1 Stopover (BOG)
AV0263, AV0115
14h 00min
Return
02/26/26
1 Stopover (BOG)
AV0098, AV0262
15h 55min
Avianca ?
$735
Chicago
Santiago de Chile
Outbound
04/03/26
1 Stopover (ATL)
LA6597, LA6357
20h 30min
Return
04/16/26
1 Stopover (ATL)
LA6358, LA6161
14h 24min
LATAM Chile ?
$761
Chicago
Santiago de Chile
Outbound
04/03/26
1 Stopover (PTY)
CM0236, CM0171
13h 57min
Return
04/16/26
1 Stopover (PTY)
CM0396, CM0235
22h 04min
Copa Airlines ?
$765
Chicago
Santiago de Chile
Outbound
02/13/26
1 Stopover (YUL)
AC8962, AC0052
36h 25min
Return
02/26/26
1 Stopover (YYZ)
AC0093, AC4408
18h 14min
Air Canada ?
$770
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Chicago to Santiago de Chile

Favorite airline: LATAM Chile
The majority of passengers on the route Chicago – Santiago de Chile prefer to fly with LATAM Chile.
LATAM Chile
31 %
Copa
27 %
Spirit Airlines
15 %
Favourite connection: via Panama City
The most popular route is via Panama City and is booked by 32 % of all travelers.
Route
bookings
1 stopover Panama City-Tocumen International
27h 08min, from $ 584
32 %
1 stopover Hartsfield-Jackson Atlanta International Airport, GA
14h 08min, from $ 573
27 %
1 stopover New York - John F. Kennedy International Airport, NY
13h 54min, from $ 674
14 %

Important flight information

Flight information: Chicago - Santiago de Chile

Roundtrip from $ 660,00
Distance 8555 km
Departure airport Airport Chicago-IL, all airports (CHI)
Arrival airport Airport Santiago de Chile - Arturo Merino Benitez (SCL)
Destination country Flights to Chile
Alternative flights to Santiago de Chile
Flight destinations with a similar price
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