Flight Routes from St. Louis to San Diego

Compare cheap outbound and return flights from St. Louis (STL) to San Diego (SAN) and find the best offer from numerous airlines and travel agencies.

Trip type
Cheapest oneway flight
from€127
Cheapest roundtrip flight
from€351
Fastest outbound flight
Fastest inbound flight
non-stop flights
48x / week
Flight distance
2,504 km
Time difference

Flight schedule from St. Louis (STL) to San Diego (SAN)

Select a travel date in the flight schedule for the route from St. Louis (STL) to San Diego (SAN) and compare affordable flight deals.

offers
Active filtersnone
Matching outbound flightsSTL–SAN · 6 of 6
fromto
dep.arr.
durationstopovers
  1. November 1 – 7, 2026
  2. November 8 – 14, 2026
  3. November 15 – 21, 2026
    1. STLSAN
      nonstop
      1. Southwest Airlines
    2. STLSAN
      nonstop
      1. United Airlines
    3. STLSAN
      nonstop
      1. Southwest Airlines
    4. STLSAN
      nonstop
      1. Southwest Airlines
    5. STLSAN
      nonstop
      1. United Airlines
    6. STLSAN
      nonstop
      1. Southwest Airlines

      Tips and tricks to help you find cheap flights from St. Louis to San Diego

      Favorite airline: Spirit Airlines
      The most popular airline for flights from St. Louis to San Diego is Spirit Airlines.
      Spirit Airlines
      40 %
      Frontier Airlines
      33 %
      Delta
      20 %
      Favourite connection: via Las Vegas
      On this route, flights with a stopover in Las Vegas are the most popular.
      Route
      bookings
      1 stopover Las Vegas - McCarran International Airport, NV
      09h 06min, from $254
      50 %
      1 stopover Denver International Airport, CO
      06h 23min, from $217
      42 %
      1 stopover Detroit Metropolitan Wayne County Airport, MI
      09h 54min, from $342
      8 %

      Important flight information

      Discover more flights around St. Louis and San Diego

      Departure airport Airport St. Louis - Lambert International Airport (STL)
      Arrival airport Airport San Diego - Lindberg Field International, CA (SAN)
      Destination country Flights to United States
      Departure airport - Destination country St. Louis - Lambert International Airport - United States
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