Flights from San Francisco to Santo Domingo

Our cheapest offers for flights from San Francisco to Santo Domingo

Here you can compare cheap flights from San Francisco (SFO) to Santo Domingo (SDQ) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santo Domingo. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
San Francisco
Santo Domingo
Outbound
09/19/25
1 Stopover (PTY)
CM0383, CM0298
32h 42min
Return
09/29/25
1 Stopover (PTY)
CM0299, CM0382
12h 31min
Copa Airlines ?
$541
Best option
San Francisco
Santo Domingo
Outbound
09/19/25
1 Stopover (JFK)
B60816, B61009
11h 52min
Return
09/29/25
1 Stopover (BOS)
B61930, B60733
13h 34min
JetBlue Airways ?
$544
San Francisco
Santo Domingo
Pay attention to transfer at connecting flight
Outbound
09/19/25
4 Stopovers (MSP, DTW, FLL, MCO)
SY0396, NK2383, NK3721, NK0196, NK1567
28h 52min
Return
09/29/25
3 Stopovers (MIA, DTW, MSP)
DM2100, NK0292, NK2388, SY0393
28h 43min
Sun Country Airlines, Spirit Airlines
$554
San Francisco
Santo Domingo
Outbound
09/04/25
2 Stopovers (SAL, BOG)
AV0561, AV0071, AV0250
38h 10min
Return
09/28/25
2 Stopovers (BOG, SAL)
AV0251, AV0366, AV0562
21h 25min
Avianca
$642
found 3 days ago
San Francisco
Santo Domingo
Outbound
07/25/25
2 Stopovers (PHX, MIA)
AA2414, AA3044, AA1856
21h 00min
Return
08/17/25
1 Stopover (MIA)
AA1856, AA2426
13h 56min
American Airlines ?
$639
San Francisco
Santo Domingo
Outbound
09/19/25
2 Stopovers (SEA, MIA)
AS0922, AS0305, DM2105
21h 56min
Return
09/29/25
2 Stopovers (MIA, SEA)
DM2100, AS0305, AS1166
27h 13min
Alaska Airlines, AraJet ?
$642
San Francisco
Santo Domingo
Outbound
09/19/25
1 Stopover (PTY)
CM0383, CM0298
32h 42min
Return
09/29/25
1 Stopover (PTY)
CM0299, CM0382
12h 31min
Copa Airlines ?
$643
San Francisco
Santo Domingo
Outbound
09/04/25
1 Stopover (PTY)
CM0383, CM0128
11h 49min
Return
09/28/25
1 Stopover (PTY)
CM0464, CM0382
32h 59min
Copa Airlines ?
$646
found 3 days ago
San Francisco
Santo Domingo
Outbound
09/19/25
1 Stopover (MIA)
AA2753, AA2171
22h 06min
Return
09/29/25
2 Stopovers (MIA, LAX)
AA2171, AA0669, AA3247
18h 57min
American Airlines ?
$661
San Francisco
Santo Domingo
Outbound
09/04/25
2 Stopovers (DFW, MIA)
AA1198, AA1306, AA0368
10h 46min
Return
09/28/25
1 Stopover (MIA)
AA1026, AA2753
30h 46min
American Airlines ?
$667
found 3 days ago
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from San Francisco to Santo Domingo

Favorite airline: e.g. Aeroméxico, Avianca
Aeroméxico is the most popular airline for flights from San Francisco to Santo Domingo.
Aeroméxico
36 %
Avianca
36 %
Copa
27 %
Favourite connection: via Panama City
The most popular route is via Panama City and is booked by 50 % of all travelers.
Route
bookings
1 stopover Panama City-Tocumen International
20h 22min, from $551
50 %
2 stopovers San Salvador Guatemala City
13h 05min, from $525
33 %
2 stopovers Guadalajara Mexico City-Juarez International
13h 39min, from $586
17 %

Important flight information

Flight information: San Francisco - Santo Domingo

Roundtrip from $540.74
Distance 5520 km
Departure airport Airport San Francisco International Airport, CA (SFO)
Arrival airport Airport Santo Domingo, Dominican Republic (SDQ)
Destination country Flights to Dominican Republic
Alternative routes to Dominican Republic
Alternative flights to Santo Domingo
Flight destinations with a similar price
Flight destinations with a similar price