Flights from San Francisco to Santo Domingo

Our cheapest offers for flights from San Francisco to Santo Domingo

Here you can compare cheap flights from San Francisco (SFO) to Santo Domingo (SDQ) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santo Domingo. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Best option
San Francisco
Santo Domingo
Outbound
10/18/25
1 Stopover (ATL)
F91448, F90030
12h 22min
Return
11/17/25
1 Stopover (JFK)
B62510, B60015
15h 21min
Frontier Airlines ?
$424
San Francisco
Santo Domingo
Outbound
09/04/25
2 Stopovers (SAL, BOG)
AV0561, AV0071, AV0250
38h 10min
Return
09/28/25
2 Stopovers (BOG, SAL)
AV0251, AV0366, AV0562
21h 25min
Avianca
$642
San Francisco
Santo Domingo
Outbound
10/18/25
1 Stopover (ATL)
F91448, F90030
12h 22min
Return
11/17/25
2 Stopovers (BOG, SAL)
AV0209, AV0130, AV0560
38h 05min
Frontier Airlines
$502
San Francisco
Santo Domingo
Outbound
10/18/25
1 Stopover (ATL)
F91448, F90030
12h 22min
Return
11/17/25
2 Stopovers (BOG, SAL)
AV0209, AV0130, AV0560
38h 05min
Frontier Airlines
$508
San Francisco
Santo Domingo
Outbound
09/04/25
1 Stopover (PTY)
CM0383, CM0128
11h 49min
Return
09/28/25
1 Stopover (PTY)
CM0129, CM0382
14h 44min
Copa Airlines ?
$637
San Francisco
Santo Domingo
Outbound
09/04/25
1 Stopover (PTY)
CM0383, CM0128
11h 49min
Return
09/28/25
1 Stopover (PTY)
CM0464, CM0382
32h 59min
Copa Airlines ?
$646
San Francisco
Santo Domingo
Outbound
10/18/25
1 Stopover (MIA)
AA0445, AA0368
17h 07min
Return
11/17/25
1 Stopover (MIA)
AA0987, AA1665
10h 31min
American Airlines ?
$651
San Francisco
Santo Domingo
Outbound
10/18/25
1 Stopover (PTY)
CM0383, CM0107
22h 16min
Return
11/17/25
1 Stopover (PTY)
CM0299, CM0382
12h 59min
Copa Airlines ?
$654
San Francisco
Santo Domingo
Outbound
09/04/25
2 Stopovers (DFW, MIA)
AA1198, AA1306, AA0368
10h 46min
Return
09/28/25
1 Stopover (MIA)
AA1026, AA2753
30h 46min
American Airlines ?
$667
San Francisco
Santo Domingo
Outbound
10/18/25
1 Stopover (EWR)
UA2626, UA1471
30h 30min
Return
11/17/25
1 Stopover (EWR)
UA2489, UA1558
12h 19min
United Airlines ?
$672
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from San Francisco to Santo Domingo

Favorite airline: e.g. Aeroméxico, Avianca
Aeroméxico is the most popular airline for flights from San Francisco to Santo Domingo.
Aeroméxico
36 %
Avianca
36 %
Copa
27 %
Favourite connection: via Panama City
The most popular route is via Panama City and is booked by 50 % of all travelers.
Route
bookings
1 stopover Panama City-Tocumen International
20h 22min, from $551
50 %
2 stopovers San Salvador Guatemala City
13h 05min, from $525
33 %
2 stopovers Guadalajara Mexico City-Juarez International
13h 39min, from $586
17 %

Important flight information

Flight information: San Francisco - Santo Domingo

Roundtrip from $423.83
Distance 5520 km
Departure airport Airport San Francisco International Airport, CA (SFO)
Arrival airport Airport Santo Domingo, Dominican Republic (SDQ)
Destination country Flights to Dominican Republic
Alternative routes to Dominican Republic
Alternative flights to Santo Domingo
Flight destinations with a similar price
Flight destinations with a similar price