- Fastest flight
- non-stop flights
- 3x / week
- Flight distance
- 8,928 km
- Time difference
- Most popular airlines
- Air Europa Lineas Aereas
- Boliviana de Aviacion
- Air Europa Lineas Aereas
Flight schedule from Madrid (MAD) to Santa Cruz (VVI)
Select a travel date in the flight schedule for the route from Madrid (MAD) to Santa Cruz (VVI) and compare affordable flight deals.
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Matching outbound flightsMAD–VVI · 8 of 8
fromto
dep.arr.
durationstopovers
- Sep 27 – Oct 3, 2026
- October 4 – 10, 2026
- October 11 – 17, 2026
- MADVVInonstop
- MADVVI1 stopover
- MADVVInonstop
- MADVVInonstop
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVInonstop
Tips and tricks to help you find cheap flights from Madrid to Santa Cruz
Favorite airline: LATAM Chile
Flight tickets on the route Madrid – Santa Cruz are most frequently booked with LATAM Chile.
LATAM Chile
89 %
Avianca
11 %
Important flight information
Frequently Asked Questions (FAQ)
How long is the flight from Madrid to Santa Cruz?
A nonstop flight from Madrid to Santa Cruz typically takes around 11 hours 20 minutes. If you choose a connecting flight, allow more travel time. Typical one-stop itineraries take around 20 hours 45 minutes. For the quickest trip, a nonstop flight is usually the most comfortable choice.
Are there nonstop flights from Madrid to Santa Cruz?
Yes, there are nonstop flights from Madrid to Santa Cruz, although not necessarily every day. On average, around 3 to 4 flights per week are available. If you have flexibility with your travel dates, you will have an easier time finding a suitable nonstop connection.
Which airlines fly from Madrid to Santa Cruz?
Direct flights from Madrid to Santa Cruz are operated by, among others, Air Europa and Boliviana de Aviacion. Connecting flights with one stop are also available, for example with Avianca (via Bogota), Aerolineas Argentinas (via Buenos Aires-Ezeiza) and LATAM Chile (via Lima). If travel time matters to you, a direct flight is usually the most convenient option. Connecting flights often give you more choice of departure times and airlines.
On which days are there nonstop flights from Madrid to Santa Cruz?
Nonstop flights from Madrid to Santa Cruz operate Monday, Wednesday, Friday, Saturday and Sunday. The schedule may vary by season, so it is worth comparing several travel dates. If your preferred day does not have a nonstop flight, nearby departure days or short connecting flights may be a good alternative.
How many flights are there per day from Madrid to Santa Cruz?
On the route from Madrid to Santa Cruz, there is less than one flight per day on average. The exact number can vary by day of the week and season. If you have flexibility with your travel dates, it is worth comparing several departure days.
How many flights per week are there from Madrid to Santa Cruz?
On the route from Madrid to Santa Cruz, there are around 3 to 4 flights per week. The number of flights can vary depending on the season and day of the week. If you have flexibility, it is worth looking at several departure days.
When does the first flight from Madrid to Santa Cruz depart?
The earliest nonstop flight from Madrid to Santa Cruz usually departs at 3:05 AM. The exact departure time may vary by day of the week and airline. Early flights are especially useful if you want to make the most of your arrival day in Santa Cruz.
When does the last flight from Madrid to Santa Cruz depart?
The last nonstop flight from Madrid to Santa Cruz usually departs at 11:35 PM. Late flights can be convenient if you want to travel after work or in the evening. Do check whether it is a nonstop flight, as a connecting itinerary could push the arrival time significantly later.