Flights from Madrid to Santa Cruz

Our cheapest offers for flights from Madrid to Santa Cruz

Here you can compare cheap flights from Madrid (MAD) to Santa Cruz (VVI) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santa Cruz. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Best option
Madrid
Santa Cruz
Outbound
10/18/25
1 Stopover (BOG)
AV0027, AV0167
22h 10min
Return
11/17/25
1 Stopover (BOG)
AV0166, AV0182
24h 50min
Avianca
$994
Madrid
Santa Cruz
Outbound
10/18/25
1 Stopover (BOG)
AV0011, AV0167
38h 20min
Return
11/17/25
1 Stopover (BOG)
AV0166, AV0182
24h 50min
Avianca ?
$1,013
Madrid
Santa Cruz
Outbound
10/18/25
1 Stopover (BOG)
AV0011, AV0167
38h 20min
Return
11/17/25
1 Stopover (BOG)
AV0166, AV0010
29h 20min
Avianca ?
$1,034
Madrid
Santa Cruz
Outbound
10/18/25
1 Stopover (LIM)
LA5392, LA2406
21h 35min
Return
11/17/25
1 Stopover (LIM)
LA2407, LA2484
30h 05min
LATAM Chile
$1,076
Madrid
Santa Cruz
Outbound
10/18/25
1 Stopover (BOG)
AV0027, AV0167
22h 10min
Return
11/17/25
1 Stopover (BOG)
AV0166, AV0046
14h 30min
Avianca ?
$1,088
Madrid
Santa Cruz
Outbound
10/18/25
1 Stopover (BOG)
AV0011, AV0167
38h 20min
Return
11/17/25
2 Stopovers (LPB, BOG)
OB0685, AV0224, AV0046
19h 35min
Avianca ?
$1,181
Madrid
Santa Cruz
Outbound
10/18/25
2 Stopovers (BOG, LPB)
AV0027, AV0239, OB0660
27h 05min
Return
11/17/25
direct
OB0776
11h 40min
Avianca, Boliviana de Aviacion ?
$1,310
Madrid
Santa Cruz
Outbound
10/18/25
1 Stopover (BOG)
AV0011, AV0167
38h 20min
Return
11/17/25
1 Stopover (BOG)
AV0166, AV0182
24h 50min
Avianca ?
$1,955
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Madrid to Santa Cruz

Favorite airline: LATAM Chile
Flight tickets on the route Madrid – Santa Cruz are most frequently booked with LATAM Chile.
LATAM Chile
89 %
Avianca
11 %
Favourite connection: via Sao Paulo
On this route, flights with a stopover in Sao Paulo are the most popular.
Route
bookings
1 stopover Sao Paulo Guarulhos International Airport
26h 40min, from $681
56 %
1 stopover Lima
32h 25min, from $737
33 %
1 stopover Bogota
38h 10min, from $1,795
11 %

Important flight information

Flight information: Madrid - Santa Cruz

Roundtrip from $993.35
Flight duration min. 11:30 / max. 11:45
Return flight duration min. 11:05/ max. 11:30
Distance 8928 km
Flights per week 9
Departure airport Airport Madrid-Barajas (MAD)
Departure country Flights from Spain
Arrival airport Airport Santa Cruz Viru Viru International (VVI)
Destination country Flights to Bolivia
Flight destinations with a similar price