Flights from Madrid to Santa Cruz

Our cheapest offers for flights from Madrid to Santa Cruz

Here you can compare cheap flights from Madrid (MAD) to Santa Cruz (VVI) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santa Cruz. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Madrid
Santa Cruz
Outbound
06/18/25
1 Stopover (BOG)
AV0183, AV8382
18h 40min
Return
07/15/25
1 Stopover (BOG)
AV8385, AV0026
22h 45min
Avianca
$898
Best option
Madrid
Santa Cruz
Outbound
09/19/25
direct
UX0025
11h 15min
Return
09/29/25
direct
UX0026
10h 50min
Air Europa Lineas Aereas
$927
Madrid
Santa Cruz
Outbound
06/18/25
2 Stopovers (LIM, LPB)
LA5392, LA2400, OB0664
27h 35min
Return
07/15/25
2 Stopovers (LPB, LIM)
OB0685, LA2401, LA1605
25h 50min
LATAM Chile, Boliviana de Aviacion
$1,057
Madrid
Santa Cruz
Outbound
09/19/25
2 Stopovers (AMS, PTY)
KL1500, KL0757, CM0127
46h 25min
Return
09/29/25
2 Stopovers (PTY, AMS)
CM0220, KL0758, KL1501
39h 20min
KLM, Copa Airlines ?
$921
Madrid
Santa Cruz
Outbound
09/19/25
direct
UX0025
11h 15min
Return
09/29/25
direct
UX0026
10h 50min
Air Europa Lineas Aereas
$930
Madrid
Santa Cruz
Outbound
09/19/25
direct
UX0025
11h 15min
Return
09/29/25
direct
UX0026
10h 50min
Air Europa Lineas Aereas ?
$944
Madrid
Santa Cruz
Outbound
09/19/25
direct
UX0025
11h 15min
Return
09/29/25
direct
UX0026
10h 50min
Air Europa Lineas Aereas
$952
Madrid
Santa Cruz
Outbound
09/19/25
direct
UX0025
11h 15min
Return
09/29/25
direct
UX0026
10h 50min
Air Europa Lineas Aereas ?
$965
Madrid
Santa Cruz
Outbound
09/19/25
1 Stopover (BOG)
AV0027, AV8382
22h 10min
Return
09/29/25
1 Stopover (BOG)
AV8385, AV0046
14h 35min
Avianca ?
$974
Madrid
Santa Cruz
Outbound
09/19/25
direct
UX0025
11h 15min
Return
09/29/25
direct
UX0026
10h 50min
Air Europa Lineas Aereas
$997
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Madrid to Santa Cruz

Favorite airline: LATAM Chile
Flight tickets on the route Madrid – Santa Cruz are most frequently booked with LATAM Chile.
LATAM Chile
89 %
Avianca
11 %
Favourite connection: via Sao Paulo
On this route, flights with a stopover in Sao Paulo are the most popular.
Route
bookings
1 stopover Sao Paulo Guarulhos International Airport
26h 40min, from $ 681
56 %
1 stopover Lima
32h 25min, from $ 737
33 %
1 stopover Bogota
38h 10min, from $ 1.795
11 %

Important flight information

Flight information: Madrid - Santa Cruz

Roundtrip from $ 897,09
Flight duration min. 11:30 / max. 11:45
Return flight duration min. 11:05/ max. 11:30
Distance 8928 km
Flights per week 9
Departure airport Airport Madrid-Barajas (MAD)
Departure country Flights from Spain
Arrival airport Airport Santa Cruz Viru Viru International (VVI)
Destination country Flights to Bolivia
Flight destinations with a similar price