Flights from Madrid to Santa Cruz

Trip type

Our cheapest offers for flights from Madrid to Santa Cruz

Here you can compare cheap flights from Madrid (MAD) to Santa Cruz (VVI) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santa Cruz. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Madrid
Santa Cruz
Outbound
03/18/26
1 Stopover (BOG)
AV0183, AV0167
20h 45min
Return
04/07/26
1 Stopover (BOG)
AV0166, AV0026
20h 35min
Avianca ?
$854
Best option
Madrid
Santa Cruz
Outbound
03/18/26
direct
UX0025
11h 20min
Return
04/07/26
direct
UX0026
10h 50min
Air Europa Lineas Aereas ?
$1,088
Madrid
Santa Cruz
Outbound
03/18/26
1 Stopover (BOG)
AV0183, AV0167
20h 45min
Return
04/07/26
1 Stopover (BOG)
AV0166, AV0182
23h 30min
Avianca ?
$886
Madrid
Santa Cruz
Outbound
03/18/26
1 Stopover (BOG)
AV0183, AV0167
20h 45min
Return
04/07/26
1 Stopover (BOG)
AV0166, AV0182
23h 30min
Avianca
$887
Madrid
Santa Cruz
Outbound
03/18/26
1 Stopover (BOG)
AV0183, AV0167
20h 45min
Return
04/07/26
1 Stopover (BOG)
AV0166, AV0026
20h 35min
Avianca ?
$940
Madrid
Santa Cruz
Outbound
03/18/26
direct
UX0025
11h 20min
Return
04/07/26
direct
UX0026
10h 50min
Air Europa Lineas Aereas
$1,110
Madrid
Santa Cruz
Outbound
03/18/26
direct
UX0025
11h 20min
Return
04/07/26
direct
UX0026
10h 50min
Air Europa Lineas Aereas
$1,122
Madrid
Santa Cruz
Outbound
03/18/26
direct
UX0025
11h 20min
Return
04/07/26
direct
UX0026
10h 50min
Air Europa Lineas Aereas ?
$1,161
Madrid
Santa Cruz
Outbound
03/18/26
direct
UX0025
11h 20min
Return
04/07/26
direct
UX0026
10h 50min
Air Europa Lineas Aereas ?
$2,110
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Madrid to Santa Cruz

Favorite airline: LATAM Chile
Flight tickets on the route Madrid – Santa Cruz are most frequently booked with LATAM Chile.
LATAM Chile
89 %
Avianca
11 %
Favourite connection: via Sao Paulo
On this route, flights with a stopover in Sao Paulo are the most popular.
Route
bookings
1 stopover Sao Paulo Guarulhos International Airport
26h 40min, from $ 681
56 %
1 stopover Lima
32h 25min, from $ 737
33 %
1 stopover Bogota
38h 10min, from $ 1.795
11 %

Important flight information

Flight information: Madrid - Santa Cruz

Roundtrip from $ 853,70
Flight duration min. 11:30 / max. 11:45
Return flight duration min. 11:05/ max. 11:30
Distance 8928 km
Flights per week 9
Departure airport Airport Madrid-Barajas (MAD)
Departure country Flights from Spain
Arrival airport Airport Santa Cruz Viru Viru International (VVI)
Destination country Flights to Bolivia
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