Flight Routes from Madrid to Santa Cruz

Trip type

Our cheapest offers for flights from Madrid to Santa Cruz

Here you can compare cheap flights from Madrid (MAD) to Santa Cruz (VVI) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Santa Cruz. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Best option
Madrid
Santa Cruz
Outbound
06/25/26
1 Stopover (BOG)
AV0027, AV0167
24h 20min
Return
06/30/26
direct
OB0772
10h 50min
Avianca ?
$1,168
Madrid
Santa Cruz
Outbound
06/25/26
1 Stopover (BOG)
AV0027, AV0167
24h 20min
Return
06/30/26
direct
UX0026
10h 50min
Avianca
$1,203
Madrid
Santa Cruz
Outbound
06/25/26
1 Stopover (BOG)
AV0027, AV0167
24h 20min
Return
06/30/26
direct
IB7797
10h 50min
Avianca ?
$1,218
Madrid
Santa Cruz
Outbound
06/25/26
1 Stopover (BOG)
AV0027, AV0167
24h 20min
Return
06/30/26
direct
UX0026
10h 50min
Avianca
$1,229
Madrid
Santa Cruz
Outbound
06/25/26
1 Stopover (BOG)
AV0027, AV0167
24h 20min
Return
06/30/26
direct
UX0026
10h 50min
Avianca ?
$1,282
Madrid
Santa Cruz
Outbound
06/25/26
1 Stopover (EZE, AEP)
AR1133, AR1368
35h 05min
Return
06/30/26
1 Stopover (AEP, EZE)
AR1369, AR1132
32h 50min
Aerolineas Argentinas
$1,313
Madrid
Santa Cruz
Outbound
06/25/26
1 Stopover (BOG)
AV0027, AV0167
24h 20min
Return
06/30/26
2 Stopovers (LPB, BOG)
OB0681, AV0224, AV0046
23h 10min
Avianca ?
$1,495
Madrid
Santa Cruz
Outbound
06/25/26
2 Stopovers (IST, SCL)
TK1860, TK0215, OB1723
51h 00min
Return
06/30/26
direct
UX0026
10h 50min
Turkish Airlines, Boliviana de Aviacion ?
$1,631
Prices based on recent searches, subject to last-minute changes
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Tips and tricks to help you find cheap flights from Madrid to Santa Cruz

Favorite airline: LATAM Chile
Flight tickets on the route Madrid – Santa Cruz are most frequently booked with LATAM Chile.
LATAM Chile
89 %
Avianca
11 %
Favourite connection: via Sao Paulo
On this route, flights with a stopover in Sao Paulo are the most popular.
Route
bookings
1 stopover Sao Paulo Guarulhos International Airport
26h 40min, from 681 $
56 %
1 stopover Lima
32h 25min, from 737 $
33 %
1 stopover Bogota
38h 10min, from 1.795 $
11 %

Important flight information

Flight information: Madrid - Santa Cruz

Roundtrip from 1.167,40 $
Flight duration min. 11:30 / max. 11:45
Return flight duration min. 11:05/ max. 11:30
Distance 8928 km
Flights per week 9
Departure airport Airport Madrid-Barajas (MAD)
Departure country Flights from Spain
Arrival airport Airport Santa Cruz Viru Viru International (VVI)
Destination country Flights to Bolivia
Flight destinations with a similar price