Flight Routes from St. Louis to Knoxville

Compare cheap outbound and return flights from St. Louis (STL) to Knoxville (TYS) and find the best offer from numerous airlines and travel agencies.

Trip type
Cheapest roundtrip flight
from€296
Fastest flight
non-stop flights
4x / week
Flight distance
652 km
Time difference

Flight schedule from St. Louis (STL) to Knoxville (TYS)

Select a travel date in the flight schedule for the route from St. Louis (STL) to Knoxville (TYS) and compare affordable flight deals.

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Matching outbound flightsSTL–TYS · 1 of 1
fromto
dep.arr.
durationstopovers
  1. Sep 27 – Oct 3, 2026
  2. October 4 – 10, 2026
  3. October 11 – 17, 2026
    No flights could be found for the active filters.
    1. STLTYS
      nonstop
      1. Southwest Airlines

      Important flight information

      Discover more flights around St. Louis and Knoxville

      Departure airport Airport St. Louis - Lambert International Airport (STL)
      Arrival airport Airport Knoxville, TN (TYS)
      Destination country Flights to United States
      Departure airport - Destination country St. Louis - Lambert International Airport - United States
      Alternative routes to United States
      Alternative flights to Knoxville
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