Flights from Santo Domingo to Panama City

Our cheapest offers for flights from Santo Domingo to Panama City

Here you can compare cheap flights from Santo Domingo (SDQ) to Panama City (PTY) for one-way or return trips. The following offers were searched for and found on idealo during the last few days. Or start your own flight search to Panama City. Prices and availability may change at any time.

Outbound Return Airlines Shop Baggage Price
Santo Domingo
Panama City
Outbound
10/31/25
1 Stopover (BOG)
AV0251, AV0040
07h 55min
Return
-
Avianca
$228
Santo Domingo
Panama City
Outbound
11/02/25
1 Stopover (BOG)
AV0251, AV0040
08h 15min
Return
12/05/25
1 Stopover (BOG)
AV0041, AV0250
12h 55min
Avianca ?
$469
Best option
Santo Domingo
Panama City
Outbound
11/06/25
direct
CM0108
02h 37min
Return
11/21/25
direct
CM0268
02h 30min
Copa Airlines ?
$560
Santo Domingo
Panama City
Outbound
11/06/25
1 Stopover (BOG)
AV0251, AV0058
16h 05min
Return
11/21/25
1 Stopover (BOG)
AV0057, AV0208
16h 30min
Avianca
$477
Santo Domingo
Panama City
Outbound
11/06/25
1 Stopover (BOG)
AV0209, AV0060
05h 35min
Return
11/21/25
1 Stopover (BOG)
AV0059, AV0250
06h 05min
Avianca
$525
Santo Domingo
Panama City
Outbound
11/02/25
direct
CM0267
02h 35min
Return
12/05/25
direct
CM0463
02h 30min
Copa Airlines ?
$563
Santo Domingo
Panama City
Outbound
11/02/25
direct
CM0108
02h 37min
Return
12/05/25
direct
CM0128
02h 31min
Copa Airlines
$571
Santo Domingo
Panama City
Outbound
11/06/25
1 Stopover (BOG)
AV0209, AV0060
05h 35min
Return
11/21/25
1 Stopover (BOG)
AV0061, AV0208
19h 30min
Avianca ?
$578
Santo Domingo
Panama City
Outbound
11/02/25
direct
CM0267
02h 35min
Return
12/05/25
direct
CM0128
02h 31min
Copa Airlines ?
$619
Santo Domingo
Panama City
Outbound
11/02/25
1 Stopover (MIA)
AA2099, AA0315
25h 30min
Return
12/05/25
1 Stopover (MIA)
AA2964, AA2145
08h 00min
American Airlines ?
$656
Prices based on recent searches, subject to last-minute changes
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Important flight information

Flight information: Santo Domingo - Panama City

Cheapest outbound flight from $227.94
Roundtrip from $468.60
Flight duration min. 02:36 / max. 02:44
Return flight duration min. 02:23/ max. 02:28
Distance 1478 km
Flights per week 38
Departure airport Airport Santo Domingo, Dominican Republic (SDQ)
Departure country Flights from Dominican Republic
Arrival airport Airport Panama City-Tocumen International (PTY)
Destination country Flights to Panama
Flight destinations with a similar price
Flight destinations with a similar price