- Roanoke (ROA) Chicago O'Hare (ORD)
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3–8 non-stop flights per dayat least 1h 49minfrom $246 - Roanoke (ROA) Frankfurt (FRA)
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only flights with stopoverat least 10h 30minfrom $615 - Roanoke (ROA) Wilmington (ILM)
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only flights with stopoverat least 2h 57minfrom $300